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Digging for known genetic mutations underlying inherited bone and cartilage characteristics and disorders in the dog and cat

Journal: Veterinary and Comparative Orthopaedics and Traumatology (VCOT)
ISSN: 0932-0814
DOI: https://doi.org/10.3415/VCOT-16-02-0037
Issue: 2016: Issue 4 2016
Pages: 269-276
Ahead of Print: 2016-05-18

Digging for known genetic mutations underlying inherited bone and cartilage characteristics and disorders in the dog and cat

B. Haase (1), H. Mazrier (1), C. M. Wade (1)

(1) School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, Sydney, Australia

Keywords

canine, bone, cartilage, Feline, gene, inherited disorders, genetic mutation

Summary

Gene mapping projects for many traits in both dogs and cats have yielded new knowledge. Both researchers and the public alike have been fascinated by the inheritance of breed characteristic phenotypes and sporadic disorders. It has been proposed that selective breeding practices have on occasion generated alterations in structure that might be harmful. In this review, simply inherited disorders and characteristics affecting bone and cartilage for which a putative mutation is known are collected. A better understanding of the known inherited basis of skeletal conditions and disorders will assist veterinarians to improve their diagnoses and increase their effectiveness on advising clients on the prevention, management, prognosis and possible treatment of the conditions.

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